Dra. Vilma Regina Martins

Sobre

Superintendente de Pesquisa (CIPE), chefe do grupo de Biologia Tumoral, docente da pós-graduação da Fundação Antônio Prudente – A.C.Camargo Cancer Center. Participa do corpo editorial dos periódicos Journal of Neurochemistry, Brazilian Journal of Medical and Biological Research e Applied Cancer Research. Foi Presidente da Sociedade Brasileira de Biologia Celular, Membro do Conselho da International Society for Neurochemistry (2010-2013), Chair do Committee for Aid, Education in Neurochemistry da International Society for Neurochemistry e International Fellow do Howard Hughes Medical Institute (2005-2010).

Formação

Graduação em Farmácia e Bioquimica pela Universidade de São Paulo (USP), mestrado e doutorado em Ciências Biológicas (Bioquímica) pela Universidade de São Paulo (USP).

Contato

Telefone: (11) 2189-5000 - ramal: 5035
E-mail: vmartins@accamargo.org.br

Vilma Martins
  • Biologia celular de tumores
  • Biomarcadores
  • Vesículas extracelulares
  • Doenças por prions

Aberrant expression of RSK1 characterizes high-grade gliomas with immune infiltration.
Hajj GN, da Silva FF, de Bellis B, Lupinacci FCS, Bellato HM, Cruz JR, Segundo CNC, Faquini IV, Torres LC, Sanematsu PI, Begnami MD, Martins VR, Roffé M. MOLECULAR ONCOLOGY. 2020 Jan;14(1):159-179. doi: 10.1002/1878-0261.12595. PMID: 31701625

Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co-chaperone STI1.
Lackie RE, Razzaq AR, Farhan SMK, Qiu LR, Moshitzky G, Beraldo FH, Lopes MH, Maciejewski A, Gros R, Fan J, Choy WY, Greenberg DS, Martins VR, Duennwald ML, Lerch JP, Soreq H, Prado VF, Prado MAM.  JOURNAL OF NEUROCHEMISTRY. 2020 Jun;153(6):727-758.  doi: 10.1111/jnc.14882. PMID: 31562773

Rab5C enhances resistance to ionizing radiation in rectal cancer.
Baptistella AR, Landemberger MC, Dias MVS, Giudice FS, Rodrigues BR, da Silva PPCE, Cassinela EK, Lacerda TC, Marchi FA, Leme AFP, Begnami MD, Aguiar S Jr, Martins VR. JOURNAL OF MOLECULAR MEDICINE. 2019 Jun;97(6):855-869. doi: 10.1007/s00109-019-01760-6. PMID: 30968159

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
Théry et al. JOURNAL OF EXTRACELLULAR VESICLES. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750. PMID: 30637094

Loss of STI1-mediated neuronal survival and differentiation in disease-associated mutations of prion protein.
Landemberger MC, de Oliveira GP, Machado CF, Gollob KJ, Martins VR. JOURNAL OF NEUROCHEMISTRY. 2018 Jun;145(5):409-416. doi: 10.1111/jnc.14305. PMID: 29337365

PRNP/prion protein regulates the secretion of exosomes modulating CAV1/caveolin-1-suppressed autophagy.
Dias MV, Teixeira BL, Rodrigues BR, Sinigaglia-Coimbra R, Porto-Carreiro I, Roffé M, Hajj GN, Martins VR. AUTOPHAGY. 2016 Nov;12(11):2113-2128. doi: 10.1080/15548627.2016.1226735. PMID: 27629560

Disruption of prion protein-HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival.
Lopes MH, Santos TG, Rodrigues BR, Queiroz-Hazarbassanov N, Cunha IW, Wasilewska- Sampaio AP, Costa-Silva B, Marchi FA, Bleggi-Torres LF, Sanematsu PI, Suzuki SH, Oba-Shinjo SM, Marie SK, Toulmin E, Hill AF, Martins VR. ONCOGENE. 2015 Jun;34(25):3305-14. doi: 10.1038/onc.2014.261. PMID: 25151961

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Peinado H, Alečković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta- Redondo M, Williams C, García-Santos G, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D. NATURE MEDICINE. 2012 Jun;18(6):883-91. doi: 10.1038/nm.2753. PMID: 22635005

Metabotropic glutamate receptors transduce signals for neurite outgrowth after after binding of the prion protein to laminin 1 chain.
Beraldo FH, Arantes CP, Santos TG, Machado CF, Roffe M, Hajj GN, Lee KS, Magalhaes AC, Caetano FA, Mancini GL, Lopes MH, Americo TA, Magdesian MH, Ferguson SSG, Linden R, Prado MAM, Martins VR. FASEB Journal. 2011 Jan;25(1):265-79. doi: 10.1096/fj.10-161653. PMID: 20876210

Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR.
Roffe M, Beraldo FH, Bester R, Nunziante M, Bach C, Mancini G, GILCH S, Vorberg I, Castilho BA, Martins VR*, Hajj GNM*. PNAS. 2010 Jul 20;107(29):13147-52. doi: 10.1073/pnas.1000784107. PMID: 20615969. * Authors with equal participation.